A form of post-translational modification of protein structure involving the transfer to protein of the ADP-ribosyl moiety of NAD. Believed to play a part in normal cellular regulation as well as in the mode of action of several bacterial toxins.

Dictionary of molecular biology. 2004.

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  • ADP-ribosylation — is a posttranslational modification of proteins that involves the addition of one or more ADP and ribose moieties. [cite journal |author=Belenky P, Bogan KL, Brenner C |title=NAD+ metabolism in health and disease |journal=Trends Biochem. Sci.… …   Wikipedia

  • ADP ribosylation factor — Pfam box Symbol = Arf Name = width =250 caption =Membrane bound ADP ribosylation factor like protein 2 (ARL2 mouse, red), complex with phosphodiesterase delta (yellow) (PDB3|1ksg) Blue dots show hydrocarbon boundary of the lipid bilayer Pfam=… …   Wikipedia

  • ADP-ribosylation factor — Ubiquitous GTP binding protein, approximately 20 kD, N myristoylated, stimulates cholera toxin ADP ribosylation. Mediates binding of non clathrin coated vesicles and AP1 (adaptor protein 1) of clathrin coated vesicles to Golgi membranes. At least …   Dictionary of molecular biology

  • ADP-ribose diphosphatase — (EC number| is an enzyme that catalyzes a hydrolysis reaction in which water nucleophillicly attacks ADP ribose to produce AMP and D ribose 5 phosphate. Enzyme hydrolysis occurs by the breakage of a phosphoanhydride bond and is dependent …   Wikipedia

  • ribosylation — The covalent attachment of one or more ribosyl groups to a molecule (usually a macromolecule). ADP r. covalent attachment of an ADP ribosyl moiety to a macromolecule; E.G., the action of diphtheria toxin …   Medical dictionary

  • NAD(P)(+)—protein-arginine ADP-ribosyltransferase — NAD(P)+ protein arginine ADP ribosyltransferase Identifiers EC number CAS number 81457 93 4 …   Wikipedia

  • NAD(+)—diphthamide ADP-ribosyltransferase — NAD+ diphthamide ADP ribosyltransferase Identifiers EC number CAS number 52933 21 8 …   Wikipedia

  • NAD(+)—dinitrogen-reductase ADP-D-ribosyltransferase — NAD+ dinitrogen reductase ADP D ribosyltransferase Identifiers EC number CAS number 117590 45 1 …   Wikipedia

  • poly(ADP-ribose) polymerase — (= PARP) (EC An abundant nuclear protein activated by DNA nicks and important in DNA repair. PolyADP ribosylation, brought about by ADP ribosyl protein ligase, is a post transcriptional modification of proteins and p53 is one of the… …   Dictionary of molecular biology

  • ARF1 — ADP ribosylation factor 1, also known as ARF1, is a human gene. PBB Summary section title = summary text = ADP ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide binding… …   Wikipedia

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